Modeling resistance to vemurafenib using integrative approaches: pitfalls and opportunities

Abstract

Drug resistance against targeted inhibitors is a complex problem that prevents efficient treatment of many tumors. Drug resistance can occur on multiple levels, requiring the acquisition and integration of system-wide data. We review the pitfalls of data integration across different layers of biology together with possible approaches to integrate the data. Additionally, we propose a model that enables the identification of mechanisms that underlie drug resistance through the integration of different layers of biological data.