Noncoding RNAs and Chromatin

Abstract

During embryonic development organisms need to establish different cell types to carry out specific functions. Gene expression regulation through chromatin changes has more and more been found to play a major role in cellular differentiation. RNA has also been found to be a player in gene expression regulation through mechanisms like RNA interference. Recent studies show a great connection between RNA and chromatin, though this field is in a very early stage. Here I discuss these recent findings in the RNA and chromatin fields, focusing in noncoding RNAs. I will go through the mechanisms by which noncoding RNAs can regulate chromatin and gene expression. Through examples I will argue in favour that noncoding RNAs are important general players in chromatin remodelling and gene expression.