The Regeneration of Intestinal Tissue with Adult Stem cells: The transplantation of human intestinal stem cells (organoids) as an alternative to organ transplantation

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Master Thesis

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Abstract

This thesis gives a comprehensive review of research currently being carried out using intestinal stem cell derived intestinal organoids as an alternative to organ transplantation. By providing an in depth analysis of current knowledge, experimental methodologies and postulated future work, this body of work illustrates the future use of intestinal organoids to treat chronic diseases of the intestine. Through this treatment approach, patients will be given the hope of living a life independent of medication and artificial (parenteral) feeding.

Keywords

Intestine, organoids, transplantation, Wnt pathway, Notch pathway, growth hormones, stem cell, intestinal epithelium, gastroenterology

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