The biodistribution of holmium loaded microspheres in intratumoural injections

Abstract

This pilot study has demonstrated that it is possible to qualify the holmium microspheres but the quantification of the Ho-MS still proves to be difficult. The magnetic resonance and computer tomography imaging are valuable image modalities for the placing of in vivo injections, mapping the gross distribution of the Ho-MS in tumour tissue and providing a preliminary and minimal concentration/dose studies. Further research is required to optimise the mapping of the biodistribution of holmium microspheres in intratumoural injections. With new technology and knowledge, it is possible to further develop intratumoural holmium treatment in veterinary and human medicine.