'Molecular basis of cognitive decline in multiple sclerosis’

Abstract

Multiple sclerosis is a neurodegenerative disorder studied from the beginning of the 20th century with many unanswered questions so far. For many years, main attention was given to the white matter areas and developing technologies and techniques that would further shed light to the mysteries of this disease. Even though the implication of grey matter was originally noticed in the 1960s, it was at the beginning of the 21st century, that its importance became greater and grey matter damage was found to be more extensive and frequent than lesions in white matter. Attention to grey matter areas has enhanced as the cognitive deficits that accompany multiple sclerosis much more often than wan initially assumed were more linked to it. This report presents evidence of the molecules in grey matter areas that underlie the cognitive impairment in multiple sclerosis.